Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Guiyedi, Vincent; Bécavin, Christophe; Herbert, Fabien; Gray, Julian; Cazenave, Pierre-André; Kombila, Maryvonne; Crisanti, Andrea; Fesel, Constantin; Pied, Sylviane

http://hdl.handle.net/10400.7/413

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Authors

Cazenave, Pierre-André

Abstract(s)

Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children.